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General Properties of Cell and Cell Examination Methods, Cell Membrane, Cell membrane transport, Apical, lateral and basal surface properties of cell membrane, Cell Skeleton, Extracellular Matrix and Receptors, Nucleus, Nucleolus, Mitochondria, Endoplasmic Reticulum, Ribosome, Golgi, Lysosome and Peroxisome, Vakuol, Sentrosomes and Plastids, Nucleic Acids (DNA) - DNA Replication, Nucleic Acids (RNA and Varieties), Transcription-Translational-Recombination, Cell divisions (mitosis and meiosis)
Learning of the embryological development, macroscopic and microscopic structures of internal and external genital organs constituting male and female system and its association with clinic.
To define and associate with clinical knowledge; the infertility causes in the male and female reproductive systems, to learn how to perform a spermiogram and to learn sperm preparation techniques.
SABE 551 Scientific Foundations
SABE 552 Preparing A Scientific Research Project
UB 551 MOLECULAR, CELL CULTURE and HISTOLOGY PRACTICALS
Learning of the physiology and functions of the male and female reproductive system and their relations with the clinic
UB 552 FUNCTIONAL PROPERTIES OF THE REPRODUCTIVE SYSTEM
Functional properties of reproductive system
UB 553 MOLECULAR MECHANISMS OF FERTILISATION AND IMPLANTATION
In the course, firstly it will deal with the stages of sperm and oocyte fertilization and the enzymes, proteins, factors and receptors that produce sperm and oocyte at these stages. The hormonal and molecular mechanisms of fertilization and implantation will be shed light on. Subsequently, the preparation process of the uterus and the maternal and embryonic factors involved in implantation and their association with the clinic will be discussed. The changes from the zygote stage to the blastocyst stage and the stages of implantation will be explained. At the time of the implantation window, interactions between the invasive blastocyst and the receptive endometrium and the importance of microenvironment will be discussed. The factors and molecules involved in the maternal and embryonic interaction in the implantation area will be discussed. Cases of normal implantation or localization failure and total implantation failure will be discussed.
UB 554 CELL SIGNALLING PATHWAYS IN EMBRYOGENESIS
Once the steps of signal transduction are identified; endocrine, paracrine and juxtacrine signal transduction, signal molecules in protein and steroid structure will be described. Significant signal pathways involved in embryo development and associated clinical conditions will be discussed.
UB 555 PLASENTA AND FETAL MEMBRANES - ASSOCIATED PATHOLOGY AND IMMUNOLOGY
After discussing how the immune system distinguishes between friendly and hostile, the concepts of immunosurveyans and immunological tolerance will be explained. Then the complex mechanisms that the immune system uses to recognize and destroy foreign cells in the body will be explained. The fetus is immunologically foreign, why fetal rejection does not occur and it is argued which cells and mechanisms are involved in it.
UB 556 GENETICS OF REPRODUCTION AND INFERTILITY, PREIMPLANTATION GENETIC DIAGNOSIS
Genetic Basis of Hereditary Diseases; Prenatal Diagnosis; In Vitro Fertilization; Gametogenesis and Preimplantation Embryo Development; Preimplantation Genetics; Preimplantation Methods Used in Genetic Diagnosis; The Future of Preimplantation Genetic Diagnosis
UB 557 STEM CELL BIOLOGY
Introduction to stem cell biology and its history, definition of stem cells, types of stem cells, advantages and disadvantages of embryonic, mesenchymal and hematopoietic stem cells and their use, cancer stem cells, stem cell microcirculation ethical and legal applications and clinical applications of stem cells